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Resveratrol Helps The Heart Says New University Study
Resveratrol Keeps Hearts Young
June 4, 2008
Resveratrol, A natural compound found in red wine, may protect the heart against the effects of the aging process, researchers said on Tuesday.
In their study, mice were given a diet supplemented with the compound known as resveratrol starting at their equivalent of middle age until old age. These mice experienced changes in their gene activity related to aging in a way very similar to mice that were placed on a so-called calorie restriction diet that slows the aging process by greatly cutting dietary energy intake. Most striking was how the resveratrol, like calorie restriction, blocked the decline in heart function typically associated with aging, according to Tomas Prolla, a University of Wisconsin professor of genetics who helped lead the study. Much as Spaniard Juan Ponce de Leon once searched for the mythical fountain of youth, researchers now are seeking ways to extend the quality and length of human life. In some studies, animals given a diet with greatly reduced caloric intake have lived longer than animals with normal diets. But perpetual hunger is a steep price to pay for greater longevity, some researchers say. Resveratrol, found in abundance in grapes and in red wine, has drawn a lot of interest from scientists and some companies, including GlaxoSmithKline, which in April said it would pay $720 million to buy Sirtris Pharmaceuticals Inc, a company that is developing drugs that mimic the effects of resveratrol. Some studies have shown that in high doses, resveratrol extended the life span of fruit flies and worms and prevented early death in mice fed a high-fat diet. In this study, mice were given relatively low doses compared to the earlier research, and still experienced important aging-related benefits, the researchers said. The researchers began giving the resveratrol diet to the mice when they were 14 months old — their middle age — and followed the animals until they were about 30 months old. The researchers then conducted tests on cardiac function and on gene activity related to aging. “”Resveratrol at low doses can retard some aspects of the aging process, including heart aging, and it may do so by mimicking some of the effects of caloric restriction, which is known to retard aging in several tissues and extend life span,”" added Prolla, whose study was published in the scientific journal PLoS ONE. Using a method that permits simultaneous analysis of thousands of genes at the same time, the researchers found a huge overlap in the genes whose activity were changed by resveratrol and caloric restriction. They looked at the heart, brain and muscles, and said that the effect of resveratrol was strongest in the heart but did prevent some aging-related changes in the other tissues. Just because mice had these benefits does not mean people also would, although Prolla said, “”I think there’s a high likelihood that our findings are applicable to humans.”" He said he expected to see a lot of studies in the coming years on the effects of resveratrol supplementation in people.
Zinc
Zinc helps children thinkApril 10, 2005 Eleven-year-olds that took zinc supplements for five days each week had better mental performance after three months than their classmates, said researchers yesterday.
The children taking an extra 20mg of zinc responded more quickly and accurately on memory tasks and with more sustained attention than classmates who did not take the mineral.
Beneficial effects were seen regardless of the youngsters’ previous zinc status, said the researchers led by Dr James Penland from the US Agricultural Research Service’s Grand Forks Human Nutrition Research Center in North Dakota.
The findings, presented at the Experimental Biology meeting this week, suggest that there could be new demand for fortified foods and supplements for this age group.
Although zinc nutrition has been related to motor, cognitive and psychosocial function in very young children and adults, this is the first study of its effect in adolescents.
Zinc deficiency is not uncommon, even in nations such as the United States, and the risk is particularly high in adolescents, said Dr Penland, because they are undergoing rapid growth and often have poor eating habits. They may not consume enough zinc-rich foods like red meat, fish and grains.
Moreover the current recommended daily allowance is only 15mg for adults in the US, and up to 9.5 mg a day for men and 4-7 mg a day for women in the UK.
In the study, 111 girls and 98 boys consumed four ounces of fruit juice containing either 0, 10 or 20 mg of zinc gluconate each school day for 10 to 12 weeks. Students, their parents and teachers did not know who was receiving which, if any, zinc supplementation.
At the beginning and end of the study, students performed a battery of tasks designed to measure mental and motor skills, like attention, memory, problem-solving and hand-eye coordination.
Students, their parents, and teachers filled out questionnaires about the students’ mental, physical and social abilities and skills, school performance, and problems in any of these areas to provide a measure of psychosocial function.
Blood samples measured zinc status before and after the treatment.
Compared to the students who received no additional zinc, students who consumed an additional 20 mg zinc each day decreased reaction time on a visual memory task by 12 per cent versus 6 per cent; increased correct answers on a word recognition task by 9 per cent versus 3 per cent; and increased scores on a task requiring sustained attention and vigilance by 6 per cent versus 1 per cent.
Those who received only 10 mg a day, the US Recommended Dietary Allowances (RDA) for this age group, did not significantly improve performance, however.
Supplementation at either the 10 mg or 20 mg did not appear to improve motor and social skills, although girls receiving the placebo experienced a 10 per cent increase in conduct problems during the study while the behaviour of girls receiving any level of zinc supplementation remained unchanged, reported the researchers.
Previous studies have shown that zinc is needed for growth and immune function and may be important for eye-hand coordination and reasoning in very young children. It also appears to influence memory, muscle strength and endurance in adults.
Pine Bark Extract Boosts Heart Health
Pine Bark Extract Boost Diabetics’ Heart Health May 13, 2008
Supplements of extracts from French maritime pine bark reduce blood pressure and the use of blood pressure medication among diabetics, concludes results from a new study.
Blood pressure control was achieved in 58 per cent of study participants, and a halving of the use of medication, among 48 participants randomly assigned to daily supplements of pine bark extract or placebo for 12 weeks. The results of the new study, published in the May issue of the journal Nutrition Research, is of particular importance for diabetics who are reportedly two to four times more likely to suffer from heart disease than non-diabetics “”These data confirm the hypothesis that pine bark extract improves diabetes control, reduces antihypertensive medicine use, and may favour a reduction in cardiovascular disease risk in individuals with type 2 diabetes,”" wrote lead author Sherma Zibadi from the University of Arizona. Indeed, previous studies have reported potential health benefits for the extract, including hypertension, asthma, chronic venous insufficiency, osteoarthritis, deep vein thrombosis, diabetes management, and diabetic leg ulcers. The new study recruited diabetic subjects with an average age of 60 and randomly assigned them to receive daily supplements of pine bark extract (125 mg) or placebo for 12 weeks in a randomized, double-blind, placebo-controlled trial with parallel-group design. All subjects were receiving pharmaceutical anti-hypertension treatment (angiotensin- converting enzyme [ACE] inhibitors). At the end of the study, Zibadi and co-workers report that 58.3 per cent of subjects in the pine bark extract group experienced blood pressure control, defined as attaining a stable systolic blood pressure, compared to 20.8 per cent in the placebo group. Moreover, use of ACE inhibitors was reduced by 50 per cent in the group receiving the pine bark extract Improvements in measures of diabetes control were also recorded, with a 23.7 mg/dL reduction in fasting blood glucose levels in the pine bark extract group, compared to only 5.7 mg/dL in the placebo group. Improvements in LDL-cholesterol, a marker of cardiovascular health, were recorded in the pine bark extract-supplemented group. After eight and 12 weeks of supplementation, decreases of 11.6 and 12.7 mg/dL were observed, respectively, compared with placebo. Mechanism of Action In attempting to understand the benefits of the pine bark extract on cardiovascular health of the diabetics, the researchers noted that the blood pressure lowering effects may be due to a suppression of serum endothelin-1, a protein that restricts blood vessels and reported to be found in higher levels than normal in type 2 diabetics and hypertensives. On the other hand, the authors could not rule out the potential of an inhibitory effect on ACE, which could improve blood flow and subsequently blood pressure. Finally, other studies have reported a potential benefit from pine bark extract on the production of the potent vasodilator, nitric oxide (NO). Limitations About 26.5 million people are affected by diabetes in the European Union, United States, and Canada equal to four per cent of the total population. This figure is projected to increase to 40 million by 2030. In the US, there are over 20 million people with diabetes, equal to seven per cent of the population. The total costs are thought to be as much as $132 billion, with $92 billion being direct costs from medication, according to 2002 American Diabetes Association figures.
Source: Nutrition Research (Elsevier) May 2008, Volume 28, Issue 5, Pages 315-320 “”Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation”" Authors: S. Zibadi, P.J. Rohdewald, D. Park, R.R. Watson
Science Begins to Add Weight to CLA
The flurry of activity in CLA applications is being backed by a growing body of research to support the ingredient, particularly for its effects on weight loss. A review published in this month’s Journal of Nutrition supports conjugated linoleic acid’s action on weight management, concluding that it is at least in part due to regulation of glucose and fatty acid uptake and metabolism.
Conjugated linoleic acid is the common name of a group of fatty acids found in dairy products and meat. CLA isomers have been studied for their action on an impressive range of diseases, including cancer, atherosclerosis, obesity, and immune function. However as scientists begin to reveal their effects on reduction of body fat, food makers are increasingly looking at the ingredient for the valuable slimming market.
In Canada, where many of the patents for CLA are held, the dairy industry has long been studying the production of high-CLA milk. In Europe, a research centre in Ireland is studying the compound which could add significant value to its dairy industry, while in Italy, Techno Foods introduced a strawberry flavoured yoghurt naturally rich in CLA (conjugated linoleic acid) and omega-3 fatty acids this summer.
Specific CLA isomers have been shown to prevent the development of obesity in certain rodent and pig models and this has been attributed mainly to trans-10, cis-12 CLA, both in vivo and in vitro, write the University of North Carolina researchers in the review. However, CLA’s ability to modulate human obesity remains controversial because data from clinical trials using mixed isomers are conflicting.
In vitro studies by the team demonstrated that while trans-10, cis-12 CLA prevents triglyceride accumulation in human cells, cis-9, trans-11 CLA increases triglyceride content. The team concluded that the isomers’ regulation of glucose and metabolism must partly explain its mechanism on human fat.
The news is also good for supplement marketers who recently learned of research carried out by Cognis backing the long-term safety of its Tonalin CLA.
Probiotics for Health
Probiotics for Health By S.K. Dash, Ph.D.
Many health-conscious consumers today want to know when they should take probiotics. They ask whether they should wait until they are sick. If so, they ask, which illnesses respond best to probiotics? Or should they take a preventive approach and take probiotics before they get sick? What about use of probiotics with antibiotics? Today, there is no doubt that taking probiotics is as essential as a multivitamin to your health. So my reply to such questions is that a daily supplement should always be taken to maintain healthy immune and digestive function — but the supplement amount should be increased during times of stress and illness. But let’s start at the beginning.
Probiotics — What Are They?
The concept of ingesting live microorganisms for the purpose of improving one’s intestinal health and general well being can be traced back well before the beginning of the Twentieth Century to earlier eras when most foods were nonrefrigerated and instead preserved with fermentation. But the current practice of using beneficial organisms to improve and sustain health is now referred to as probiotic supplementation. Although numerous types of bacteria (and yeasts) are currently being marketed as probiotic cultures throughout the world, the two most commonly used ones are Lactobacillus and Bifidobacterium.
Probiotics — A Health Essential?
Consumers rarely consider how essential healthy bacterial populations are to their health. But the fact is that a healthy ratio of beneficial to pathogenic bacteria residing within the gastrointestinal tract is essential to good health and influences not only digestive health but also immune function, detoxification, and women’s vaginal health. Unfortunately, great numbers of people today no longer have optimally balanced ratios of beneficial to pathogenic bacteria in their body, thus allowing the “”bad guys”" to gain the upper hand. This is very dangerous and one of the reasons that digestive illnesses, as well as other types of illnesses, are becoming so prevalent. Medically prescribed antibiotic use is certainly one of the most important causes of this change in our natural flora, with travel to foreign lands a close second. But beyond these detrimental impacts on our gastrointestinal health, we face many other daunting challenges to our bacterial balance. Unless one consumes organic dairy products, for example, one is almost certainly consuming traces of antibiotics and sulfa drugs, which have a disruptive effect on bowel ecology. Our highly processed food supply has also denied our bodies the opportunity to ingest beneficial bacteria as we once did through food fermentation (widely used before refrigeration). Our water also tends to be highly chlorinated which, although important from a public health perspective, has drawbacks for individual health when it comes to adversely impacting our body’s bacterial populations. When the body’s bacterial populations are upset, many kinds of illness can result. So for daily maintenance and in times of illness it just makes sense to use a quality probiotic formula.
Prevention and Treatment of Diarrhea and Constipation: Antibiotic-associated diarrhea can be attributed in part to imbalances in intestinal microflora. Bifidobacteria have been used to successfully treat intestinal disorders and in the prevention of rotaviral diarrhea in children and adults. In fact, taking a probiotic formula with antibiotics is now considered to be standard medicine in many countries. But antibiotics and probiotics must be taken a few hours apart. Constipation is a significant problem for many people, especially the elderly. Researchers have shown that enhancing Bifidobacteria in the large intestine of constipated elderly individuals provides a significant laxative effect.
Ulcer Therapy: If you’re taking antibiotics to treat your ulcer, you should be using probiotics along with your doctor’s prescribed antibiotics. That’s the message from researchers reporting in the February 2001 issue of Digestion. Frequently, nausea, bloating, diarrhea, taste disturbances and loss of appetite are side effects from use of antibiotics to eradicate Helicobacter pylori, the bacterium thought to be the causative agent in gastric ulcers. This latest study involving 120 ulcer patients shows that persons given both antibiotics and probiotics experienced markedly reduced incidence of bloating, diarrhea and taste disturbances compared to persons given only antibiotics, and most persons given the natural remedy experienced no side effects.
Enhanced Immune Function: Most of our immune cells are produced within the gastrointestinal tract and much of our protection against orally ingested pathogens (such as salmonella) is the result of a healthy gastrointestinal environment. There is perhaps no greater protection against such food-borne pathogens than the use of probiotics to sustain this healthy environment. Recent studies show that Lactobacilli and Bifidobacteria can stimulate both general immunity and also specific antibodies to certain pathogens.
Lactose Intolerance: Dairy foods are a very important part of a healthy diet, but many of us suffer from some symptoms of lactose intolerance. Studies have shown that strains of Lactobaccilli and Bifidobacteria reduce symptoms of lactose malabsorption.
Establishment of Healthy Flora: in Babies and Infants Premature infants generally take longer to establish a characteristic intestinal flora, which can render them more susceptible to certain intestinal infections. Various strains of Bifidobacterium administered to premature infants results in populations of beneficial bacteria becoming established more quickly in their intestines compared to a control group. You will also likely find that children susceptible to middle ear infections enjoy better health when they are given probiotics (DDS®-Junior Probiotic for Children).
Editor’s Note: Dr. S. K. Dash is among the world’s leading experts today in the field of probiotics. Dr. Dash is founder of America’s leading probiotic company UAS Labs.
See the full unabridged version of this article at www.freedompressonline.com.
References Armuzzi, A., et al. “”Effect of Lactobacillus GG supplementation on antibiotic-associated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study.”" Digestion, 2001;63:1
Brain Cell Growth Boosted By DHEA Supplements
‘Anti-aging’ hormone DHEA Found to Boost Brain Cell Growth August 24, 2004
Human neural stem cells, exposed in a lab dish to the steroid DHEA, exhibit a remarkable uptick in growth rates, suggesting that the hormone may play a role in helping the brain produce new cells, according to a new study published this week in the online edition of the Proceedings of the National Academy of Sciences (PNAS).
The new work, conducted by a team of scientists at the University of Wisconsin-Madison, provides some of the first direct evidence of the biological effects of DHEA on the human nervous system, according to Clive Svendsen, the study’s senior author and an authority on brain stem cells at UW-Madison’s Waisman Center.
“What we saw was that DHEA significantly increased the division of the cells,” said Svendsen, a UW-Madison professor of anatomy and neurology. “It also increased the number of neurons produced by the stem cells, prompting increased neurogenesis of cells in culture.”
DHEA or dehydroepiandrosterone is among the most abundant naturally occurring steroids in the blood of young humans, but levels decline with age and its physiological effects are poorly understood.
A synthetic form of the hormone is sold over-the-counter as a dietary supplement in the US, thought to have anti-aging properties and to offer prevention against cancer and heart disease, Alzheimer’s and other diseases. But scientists know relatively little about the drug and its basic biological effects on humans.
“We don’t know much about DHEA, but this new work adds a piece to the puzzle,” said Svendsen, who conducted the study with colleagues Masatoshi Suzuki, Lynda S. Wright, Padma Marwah and Henry A. Lardy, all of UW-Madison. “This is the first real evidence of DHEA’s effects on human neural cells.”
Svendsen and Suzuki carried out the experiments by growing human fetal neural stem cells in culture. The cells form aggregates known as ‘neurospheres,’ which were exposed to a cocktail of DHEA and growth and inhibitory factors, and observed a 29 per cent increase in new brain cells compared to cells grown in a medium with the same factors, but without DHEA.
“We saw such a pure effect of DHEA,” Svendsen said.
“It’s the only steroid we tested that had such a direct effect on stem cell growth and new neuron formation,” according to Suzuki.
The new work is important because it provides a direct window to the controversial hormone’s effects on critical human cells. Similar studies have been conducted in mice and rats, but those models have shortcomings that are difficult to address, Svendsen notes.
“There are previous studies in rats that suggest DHEA is neuroprotective, but the problem with DHEA in rats is that it is not a major metabolite in that animal so its effects may not be the same as those seen in humans,” he said. According to Lardy, metabolic products of DHEA hormone have also been shown to aid memory retention in old mice.
Despite hints from the studies in rodents that DHEA may play a role in enhancing the brain and memory, the new findings reported in the PNAS article were a surprise, he said.
“We assumed the compounds we were testing would be more active than DHEA in brain stem cells,” Lardy explains. In previous studies, Lardy, with Wisconsin biochemistry colleagues James Ntambi and Brian Fox, showed that DHEA blocked a step in fat synthesis.
“The effects of DHEA on brain stem cells is a completely new finding,” said Lardy. “The problem of whether DHEA itself is having this effect, or if there’s another metabolite of the hormone involved, still exists.”
One of the intriguing aspects of the new work, according to Svendsen, is the possibility that DHEA could have some positive effects on the adult human brain.
It is known that DHEA amounts fall progressively during aging, and reduced levels of DHEA have been reported in both adolescents and adults with major depressive disorders. And given the fact that adult humans have neural stem cells that continue to make new neurons in some parts of the brain, there is a possibility that DHEA could play a role in moderating the genesis of new brain cells.
Fish Oil Supplements Can Be Purer Than Fish
Fish Oil Supplements Can Be Purer Than Fish
University of Southern California School of Pharmacy Detects No PCBs in Fish Oil Supplements in Health Products for Americas Top Retailers.
CARSON, Calif., Jan. 9 — As more Americans eat fish to protect themselves against heart disease and other illnesses, the scientific community debates whether toxins found in fish can do more harm than good. A recent study to be published in the journal Science found that farm raised salmon contained high levels of pollutants like PCBs and pose a health risk to humans. While the debate will continue on acceptable levels of PCB consumption in fish, consumers should understand that fish oil supplements can be purer than fish and are still safe to take.
Recognizing the serious health risks associated with PCBs found in food, Leiner Health Products asked the University of Southern California School of Pharmacy (USC) to test fish oil supplements it sells to the nation’s top retailers. Using analytical procedures approved by the Environmental Protection Agency (EPA), USC randomly analyzed fish oil supplements from 18 different lots. No PCBs, dioxins or heavy metals such as lead, cadium, mercury or arsenic were detected in any of the samples.
“We used EPA’s best method (Gas Chromatography-Electron Capture Detector (GC-ECD) to test Leiner’s fish oil capsules for PCBs. This is a complex, confirmed method of analysis that has been used for over 30 years. Our analysis supports the American Heart Association’s findings of the health benefits from consuming fish oil in the form of dietary supplements. Our research proves that people can take fish oil supplements without risking their health due to possible environmental contaminant intake,” remarked Dr. Roger Clemens, Director of Analytical Research & Services, USC School of Pharmacy.
Additional samples of Leiner’s fish oil capsules were also independently evaluated by Covance Laboratories in Madison, Wisconsin. Those findings were consistent with the USC results.
Some people believe fish oil supplements contain higher concentrations of PCBs than fish but this is not true. In order to produce the purest possible fish oil, Leiner uses a process called molecular distillation to remove pollutants. This process is similar to a water purification process that traps virtually all contaminants, resulting in a “”clean”" oil.
Molecular distillation is an excellent way to rid fish oil of PCBs, other toxins and heavy metals such as mercury, lead, cadium and arsenic to below detectable levels. While it is impossible to remove 100% of all impurities, Leiner fish oil processed using molecular distillation exceeds purity standards set by California’s Proposition 65 requirements and the EPA requirements, which are much more rigorous than FDA.