Resveratrol Helps The Heart Says New University Study
Resveratrol Keeps Hearts Young
June 4, 2008
Resveratrol, A natural compound found in red wine, may protect the heart against the effects of the aging process, researchers said on Tuesday.
In their study, mice were given a diet supplemented with the compound known as resveratrol starting at their equivalent of middle age until old age. These mice experienced changes in their gene activity related to aging in a way very similar to mice that were placed on a so-called calorie restriction diet that slows the aging process by greatly cutting dietary energy intake. Most striking was how the resveratrol, like calorie restriction, blocked the decline in heart function typically associated with aging, according to Tomas Prolla, a University of Wisconsin professor of genetics who helped lead the study. Much as Spaniard Juan Ponce de Leon once searched for the mythical fountain of youth, researchers now are seeking ways to extend the quality and length of human life. In some studies, animals given a diet with greatly reduced caloric intake have lived longer than animals with normal diets. But perpetual hunger is a steep price to pay for greater longevity, some researchers say. Resveratrol, found in abundance in grapes and in red wine, has drawn a lot of interest from scientists and some companies, including GlaxoSmithKline, which in April said it would pay $720 million to buy Sirtris Pharmaceuticals Inc, a company that is developing drugs that mimic the effects of resveratrol. Some studies have shown that in high doses, resveratrol extended the life span of fruit flies and worms and prevented early death in mice fed a high-fat diet. In this study, mice were given relatively low doses compared to the earlier research, and still experienced important aging-related benefits, the researchers said. The researchers began giving the resveratrol diet to the mice when they were 14 months old — their middle age — and followed the animals until they were about 30 months old. The researchers then conducted tests on cardiac function and on gene activity related to aging. “”Resveratrol at low doses can retard some aspects of the aging process, including heart aging, and it may do so by mimicking some of the effects of caloric restriction, which is known to retard aging in several tissues and extend life span,”" added Prolla, whose study was published in the scientific journal PLoS ONE. Using a method that permits simultaneous analysis of thousands of genes at the same time, the researchers found a huge overlap in the genes whose activity were changed by resveratrol and caloric restriction. They looked at the heart, brain and muscles, and said that the effect of resveratrol was strongest in the heart but did prevent some aging-related changes in the other tissues. Just because mice had these benefits does not mean people also would, although Prolla said, “”I think there’s a high likelihood that our findings are applicable to humans.”" He said he expected to see a lot of studies in the coming years on the effects of resveratrol supplementation in people.
Longevity Boost Tied to Specific Nutrients, Not Caloric Restriction
Longevity Boost Tied to Specific Nutrients Cutting fat and protein extends fly lifespan without calorie restriction Cutting fat and protein extends fly lifespan without cutting calories, providing further insight into the effects of diet on longevity.
Caloric restriction is known to extend lifespan in many organisms.
Linda Partridge of University College London and colleagues wanted to determine whether, at least in flies, this is due to a total reduction of calories or a reduction of particular nutrients.
So the researchers varied the nutrients in the fly’s standard lab diet of yeast and sugar.
Both yeast (which contributes protein and fat) and sugar (carbohydrates) have the same calories per gram, allowing the researchers to adjust nutrient composition without affecting the calorie count.
They found that reducing both nutrients increased the flies’ life span, but cutting out the yeast had nearly as great an effect.
Flies on a calorie-restricted diet lived 82% longer than controls, flies on the yeast-restricted diet had a 65% gain and flies on a sugar-restricted diet had just about a 9% gain.
Partridge and colleagues suggest that yeast and sugar trigger different metabolic pathways with different effects on lifespan.
The research is reported in the journal PLoS Biology Read the full text here <a href=”"http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030223″” Nutrients not Caloric Resriction Responsible for Life Extension
Organic Food Is Safer
Major Study of Pesticide Residues Shows Organic Food Is Safer May 7 — WASHINGTON — U.S. Newswire Following is a statement by Environmental Working Group (EWG) President Ken Cook: “”Conventionally grown food has significantly higher levels of pesticides, and is contaminated with residues of multiple pesticides, far more frequently than organic food. And those lower pesticide levels translate into lower risk of cancer and other health effects for consumers who eat organic food, particularly children.”"
“”These are the key findings of the first detailed study comparing pesticide residues on tens of thousands of samples of organic and conventional foods. The study also found that farming methods designed to use pesticides more sparingly also result in food residue levels that are lower than in regular food.
“”In recent years, the federal government has restricted or banned a number of pesticides out of a growing scientific recognition of the special risk these chemicals pose to children’s health. This study makes clear that the entire food supply can and should move in the direction of lower pesticide residues and thus lower health risks. The organic food industry is leading the way with a safer alternative.
“”Consumers know what to eat if they want to cut back on fat, calories or cholesterol. Now they know they should buy organic if they want to reduce pesticides in the foods they eat and feed their children.”"
The study was published in the current (May, 2002) issue of Food Additives and Contaminants, a scientific journal. It was authored by Brian Baker, Charles Benbrook, Edward Groth and Karen Lutz Benbrook.
EWG, a nonprofit environmental research organization, has published dozens of studies on the risks of pesticides to children.
Olive Oil Boosts Heart Health
FDA Announces: Olive Oil May Boost Heart Health November 8, 2004 Food containing olive oil can carry labels saying they may reduce the risk of coronary heart disease, the government says, citing limited evidence from a dozen scientific studies about the benefits of monounsaturated fats.
As long as people don’t increase the number of calories they consume daily, the Food and Drug Administration confirmed a reduction in the risk of coronary heart disease when people replace foods high in saturated fat with the monounsaturated fat in olive oil.
That means a change as simple as sauteing food in two tablespoons of olive oil instead of butter may be healthier for your heart.
“”Since CHD is the No. 1 killer of both men and women in the United States, it is a public health priority to make sure that consumers have accurate and useful information on reducing their risk,”" Lester M. Crawford, acting FDA commissioner, said in a prepared statement.
“”It’s good news for consumers,”" said Bob Bauer, president of the North American Olive Oil Association, which sought the qualified health claim on Aug. 28, 2003. “”Olive oil is a healthy product to help them fight heart disease.”"
Recent research has underscored the heart benefits from so-called Mediterranean diets high in unsaturated fats from vegetable oil, nuts and such fish as salmon and tuna. Mortality rates dropped by more than 50 percent among elderly Europeans who stuck to such diets and led healthy lifestyles, according to research published in the Journal of the American Medical Association in September.
The North American Olive Oil Association included 88 publications to back its claim for the heart-healthy benefits of olive oil. The group wanted to make the claim for monounsaturated fats contained in just one tablespoon of olive oil per day.
Olive oil and certain food containing olive oil can now indicate that “”limited and not conclusive scientific evidence suggests that eating about two tablespoons (23 grams) of olive oil daily may reduce the risk of coronary heart disease due to the monounsaturated fat in olive oil,”" the FDA concluded.
“”I think FDA just took a more conservative view,”" Bauer said. Manufacturers waited for the FDA’s precise wording before revising labels. “”I expect, over time, most every container of olive oil will have this,”" he said.
Already, American restaurants and consumers drive $450 million in olive oil sales per year. Supermarket sales in 2003 accounted for 132 million pounds of olive oil, up by nearly one-third over the past six years. Bauer said he expects the label change to spur a larger uptick in sales.
According to the American Heart Association, coronary heart disease caused 502,189 deaths — or one in five deaths — in 2001, the most current statistic available. Another 13.2 million Americans that year survived the heart attacks, chest pains and other ailments caused by coronary heart disease.
Along with lowering cholesterol, cutting out cigarettes and exercising, the group says Americans can boost heart health by eating foods low in saturated fat, cholesterol and sodium. An American Heart Association spokeswoman declined comment on the FDA’s action until it reviews the health claim.
The FDA discounted most of the submitted studies because the methodology made it difficult to tease out the effect of the monounsaturated fats in olive oil. Of a dozen studies that survived the cut, four were the most persuasive.
Thirty-three healthy young American men ate diets high in saturated fats from butter or cocoa butter, olive oil’s monounsaturated fats or polyunsaturated fats from soybean oil. The soybean and olive oil groups significantly lowered total and bad LDL cholesterol.
In another trial involving 21 middle-aged Spanish women, those with diets in which olive oil replaced 8 percent of total daily calories from saturated fats lowered their total and bad cholesterol while significantly boosting good HDL cholesterol.
Forty-one young Spanish men lowered total and bad LDL cholesterol with an olive oil diet. Levels of good cholesterol did not drop in the olive oil group, as they did for youthful peers who replaced calories from saturated fats with carbohydrates.
And 22 healthy, middle-aged Spanish men with slightly elevated cholesterol counts were put on a four-week diet high in saturated fat. Those who switched to diets high in olive oil and those who replaced calories from saturated fats with carbohydrates lowered total and bad LDL cholesterol levels.
It’s the third time the FDA granted a qualified health claim for conventional food. In March, the agency said “”supportive but not conclusive research”" shows eating 1.5 ounces of walnuts per day may reduce coronary heart disease risk. In September, it issued a similar qualified claim for the heart-healthy benefits of omega-3 fatty acids.
The FDA press release: http://www.fda.gov/bbs/topics/news/2004/NEW01129.html
Resistence to Antibiotics on Rise in US
By Serena Gordon HealthScoutNews Reporter FRIDAY, April 19 (HealthScoutNews) — In the wake of a new report that the strep throat germ is now showing significant antibiotic resistance in the United States, many people are wondering if they — or their children — are at risk. They just might be, unless all of us our dependence on antibiotics, says Philip Tierno, director of clinical microbiology at New York University Medical Center and Mt. Sinai Medical Center in New York City. “”Antibiotic resistance is more prevalent than you’d think,”" Tierno adds. There are two main reasons for it: Overprescription of antibiotics by doctors and the use of antibiotics in livestock, he says.
“”One hundred and fifty million prescriptions are written annually,”" Tierno says. “”Ninety million of those are for antibiotics, and 50 million of those are unnecessary.”" Many antibiotic prescriptions are written for sore throats, but only a small percentage of them are caused by Group A streptococci bacteria, which causes strep throat. The germ can also cause sinus, ear and skin infections. Left untreated, strep can progress into scarlet fever or the more serious rheumatic fever, with potentially fatal consequences. Young children are especially vulnerable to such complications. Strep throat is commonly treated with antibiotics, such as penicillin, or erythromycin for those who are allergic to penicillin. In yesterday’s New England Journal of Medicine report, researchers from Children’s Hospital of Pittsburgh studied a group of 100 area school children from kindergarten through eighth grade. They found that Group A streptococci was resistant to erythromycin in 48 percent of the throat cultures taken between October 2000 and May 2001. According to the researchers, this is the first time such a high level of resistance to erythromycin has been found in the United States. Similarly high levels of resistance have been reported in other countries, however, Tierno says. In Japan and Finland, he says, resistance to Group A strep has been reported at levels exceeding 50 percent. The good news, according to Tierno, is that in Japan the rate of resistance has fallen as health officials there decreased their use of erythromycin-based antibiotics. By not using these drugs, Tierno explains, the germs become vulnerable to them again. The Pittsburgh researchers followed the children for three years, and during the first two years, while they did find cases of strep, they found no signs of antibiotic resistance. It wasn’t until the third year that the antibiotic-resistant strain appeared. Tierno says this finding clearly points to overuse of antibiotics. “”What causes drug resistance is the inappropriate use of antibiotics by physicians,”" he says. But patients are partly to blame as well, he adds, because they push for inappropriate prescriptions when they’re ill. Dr. James Musser is chief of the Laboratory of Human Bacterial Pathogenesis at the National Institute of Allergy and Infectious Diseases in Hamilton, Mont. He says, “”From a national perspective, we need to be very concerned about increasing antibiotic resistance in any pathogen.”" And, he adds, we need a study that looks at a greater geographical area to assess how widespread the problem [uncovered in Pittsburgh] might be. In the meantime, he says, “”It’s important for patients to realize that not every upper-respiratory infection is of bacterial origin and to listen closely to the advice of the treating physician.”" That means patients shouldn’t badger their doctor for antibiotics unless they’re deemed necessary.
Skip Breakfast, Get Fat
Skip Breakfast, Get Fat
But more meals, if smaller, could make you thinner, study finds
FRIDAY, July 11 (HealthDayNews) — It’s a prime piece of conventional wisdom: Eat right before you go to bed and you’ll get fat.
But new research suggests that late eaters are no more likely to be overweight than anyone else. It’s what you consume the rest of the day — especially in the morning — that counts.
Americans who regularly skip breakfast are 4.5 times more likely to be fat, researchers found. But, in good news for the nibblers among us, those who eat four or more meals a day are actually on the thinner side.
“”We tend to eat because of external cues instead of internal cues — we eat until the plate’s clean. If the plate has a lot less food on it, perhaps you’ll be eating less,”" says Ruth Kava, director of nutrition with the American Council on Science and Health.
Researchers launched their study because experts don’t fully understand how eating habits — such as the timing and frequency of meals — are tied to obesity, says study co-author Yunsheng Ma, an assistant professor of epidemiology at the University of Massachusetts Medical School.
The researchers examined a national cholesterol study that took place from 1994 to 1998. A total of 499 people reported five times a year on what they ate over 24 hours.
The findings of the study appear in the current issue of the American Journal of Epidemiology.
Ma and his colleagues found people who ate more than three times a day were about half as likely to be fat as those who ate three or fewer times a day. Ma suspects the difference may have something to do with fewer spikes in blood sugar levels among the frequent eaters.
Insulin levels go up when blood sugar rises, contributing to hunger and the buildup of fat, Ma says. Similar factors may be at work among those who frequently eat breakfast or dinner away from home, he says. The study found they were 4.5 times more likely to be fat.
Someone who eats breakfast at home might settle for a small, convenient meal, Kava says. “”But if you go out, there’s all kinds of tempting things like bacon and eggs and hash browns. Maybe you tend to indulge a little bit more. You don’t have to do the work or clean up.”"
And what about the link between skipping breakfast and tipping the scales?
“”You have not broken the fast soon enough to only need a moderate amount of calories,”" says Gail Frank, a professor of nutrition at California State University at Long Beach and a spokeswoman for the American Dietetic Association. “”You are starving. How does the normal person respond? They eat, and they keep eating to compensate.”"
As for the study’s rebuttal of the time-honored belief in the fattening properties of late-night meals, Ma says more research is needed to confirm that finding.
But it makes sense, Frank says, and counteracts the “”myth”" about the hazards of midnight munching.
The body continues digesting through the night, she says, even when people are asleep and not active. “”The body doesn’t know when the lights go off,”" she says.
SOURCES: Yunsheng Ma, Ph.D., assistant professor, epidemiology, University of Massachusetts Medical School, Worcester; Ruth Kava, Ph.D, R.D. director, nutrition, American Council on Science and Health, New York City; Gail Frank, DrPH, R.D., professor, nutrition, California State University at Long Beach, and spokeswoman, American Dietetic Association; July 1, 2003, American Journal of Epidemiology
Learn About Grains
Grains By Jennifer A. Wickes
The proper term, in reference to grains, is cereal grains. The word “”cereal”" comes from Ceres, a pre-Roman goddess of agriculture. Cereal includes any plant from the grass family that produces an edible seed.
Cereals are inexpensive, have an available source of protein and the highest concentration of carbohydrates compared with any other food. Varieties Barley
Barley dates back to the Stone Ages. It is used in recipes such as bread, cereal, and soups. Most barley in the western world is now used for two reasons, for making beer and whiskey, and for animal fodder. Bulgur Wheat
Originating from the Middle East, this is wheat kernels which have been steamed, dried and crushed. Couscous
A staple in North Africa. Couscous is derived from semolina. Can be cooked and added to milk to make a porridge, fruits and honey can be added to make a dessert or you can mix a dressing into it and eat it like a salad. Kasha
This is roasted buckwheat grains. Millet
Millet is a staple grain for over a 1/3 of the world’s population, particularly in Asia and Africa. The United States uses millet almost exclusively for fodder and birdseed. Millet is rich in protein with a bland flavor, so it takes well to be cooked with other foods and spices. You prepare millet like rice, in boiling water, to make into a hot cereal or some sort of pilaf. Ground millet is used in puddings, breads and cakes. You can find millet in natural food stores, as well as Asian markets. Oats
In the 1700s, England would feed oats to their horses, yet the Scottish used to eat oats every day! Polenta / Cornmeal
Dried corn kernels that have been ground to a powder. Quinoa
A staple to the Incas. Contains the most protein than any other grain. It also contains eight essential amino acids. Quinoa is also high in unsaturated fats and lower in carbohydrates. You need to cook Quinoa like rice, and it has been compared in flavor to couscous. Can be found in natural food stores. Rice
Rice has been cultivated throughout Asia since at least 8000 BC. There are also over 7000 varieties. Rice contains iron, calcium and B- complex vitamins. Risotto
An Italian rice which is cooked as rice and can be served with a variety of meats and vegetables. Italian Arborio rice is usually used in the preparation of risotto. Rye
Rye contains less gluten that any other flour, therefore, all rye breads tend to be dense. There are a variety of different ryes, all of which are found at Natural Food Stores: medium, light, dark and pumpernickel. Sorghum
The third largest grain in the entire world, the US only use it as fodder. The only thing the US use sorghum for when speaking of human consumption, sorghum molasses, which is used to sweeten baked goods. Spelt
A cereal grain native to southern Europe, where it has been used for thousands of years. It has a nutty flavor, and can be used in lieu of wheat flour in recipes if a person is gluten intolerant. This grain can also be found in Natural Food Stores. Teff
A cereal grain native to Ethiopia, but is currently being harvested in Idaho. This grain has a nutty flavor, is high in protein, carbohydrates, calcium and iron. It can be found in Natural Food Stores. Triticale
Triticale is a hybrid of wheat and rye. It has more protein and less gluten than wheat. It comes in berries, flakes and flour. You can find this in Natural Food Stores. Triticale is usually used to make casseroles, hot cereals and pilafs. Due to the low gluten content, breads made from this grain make loaves to be very heavy, therefore using
Science Begins to Add Weight to CLA
The flurry of activity in CLA applications is being backed by a growing body of research to support the ingredient, particularly for its effects on weight loss. A review published in this month’s Journal of Nutrition supports conjugated linoleic acid’s action on weight management, concluding that it is at least in part due to regulation of glucose and fatty acid uptake and metabolism.
Conjugated linoleic acid is the common name of a group of fatty acids found in dairy products and meat. CLA isomers have been studied for their action on an impressive range of diseases, including cancer, atherosclerosis, obesity, and immune function. However as scientists begin to reveal their effects on reduction of body fat, food makers are increasingly looking at the ingredient for the valuable slimming market.
In Canada, where many of the patents for CLA are held, the dairy industry has long been studying the production of high-CLA milk. In Europe, a research centre in Ireland is studying the compound which could add significant value to its dairy industry, while in Italy, Techno Foods introduced a strawberry flavoured yoghurt naturally rich in CLA (conjugated linoleic acid) and omega-3 fatty acids this summer.
Specific CLA isomers have been shown to prevent the development of obesity in certain rodent and pig models and this has been attributed mainly to trans-10, cis-12 CLA, both in vivo and in vitro, write the University of North Carolina researchers in the review. However, CLA’s ability to modulate human obesity remains controversial because data from clinical trials using mixed isomers are conflicting.
In vitro studies by the team demonstrated that while trans-10, cis-12 CLA prevents triglyceride accumulation in human cells, cis-9, trans-11 CLA increases triglyceride content. The team concluded that the isomers’ regulation of glucose and metabolism must partly explain its mechanism on human fat.
The news is also good for supplement marketers who recently learned of research carried out by Cognis backing the long-term safety of its Tonalin CLA.
Acetyl L-Carntine vs. L-Carnitine
The Essential Difference Between the Carnitines
Do you lack energy, or feel tired and physically or mentally unprepared to take on the tasks of the day? This is not unusual, especially as we age, and today’s topic may help explain some of the reasons for this energy deficit.
Two natural compounds produced by our tissues, L-carnitine and acetyl-L-carnitine (ALC), are similar in that both have identical chemical core structures. However, one (ALC) contains an extra component, an acetic acid bound to the core molecule (in what is known as an ester linkage). It turns out that this extra chemical piece makes a significant difference in how this molecule behaves in our body relative to its non-acetylated cousin, L-carnitine. These differences are described below, but first a brief summary of how these molecules normally function in our body.
L-carnitine functions as a vehicle to ferry fat constituents (fatty acids) across a membrane barrier into the cell’s energy-producing machine, the mitochondria, where the fat is converted to energy. Equally important, L-carnitine works in the reverse direction, too. It ferries toxic products produced during fat metabolism out of the mitochondria. This latter step helps maintain the mitochondria as clean-burning, energy-efficient machines.
We are all aware of the fact that as we age, our energy level diminishes. This decrease in energy parallels a decrease in the plasma level of L-carnitine. L-carnitine also decreases under conditions of stress, both psychological and physical. Consequently, it is described as a conditionally essential nutrient. This simply means that when our bodies cannot produce enough of it to meet demand, we need to increase the intake of this nutrient.
Acetyl-L-carnitine is just as active as L-carnitine in transporting fatty acids into the mitochondria. However, as described below, that extra acetyl group confers additional properties to this form of L-carnitine, which make it superior to its non-acetylated cousin. Both compounds increase energy Acetyl L-Carnitine or ALC Physical Energy Fat Metabolism Brain Protection Neurotransmission
Experiments with rats show a dramatic decrease (between 50-70%) in the activity level of old rats as compared to the young animal. Old rats, too, get tired with age! This decrease, as mentioned above, parallels a decrease in the amount of L-carnitine present in the animal’s tissues and blood.
This observation led researchers to investigate whether the old energy-deficient animals could be transformed into more energetic, youthful animals by feeding them a diet enriched with L-carnitine. Supplying L-carnitine to the diet increased the ambulatory activity of the old rats almost two-fold. The experiment was repeated with ALC, and it too increased the animals’ activity level to about an equal degree. So both compounds worked equally well in improving the old rats’ energy levels. ALC protects the brain
One of the two cousins, ALC, stands out with respect to its effects on the brain and nervous system. First, ALC is more effectively transported into the central nervous system. It more readily traverses the blood-brain barrier
Brain Cell Growth Boosted By DHEA Supplements
‘Anti-aging’ hormone DHEA Found to Boost Brain Cell Growth August 24, 2004
Human neural stem cells, exposed in a lab dish to the steroid DHEA, exhibit a remarkable uptick in growth rates, suggesting that the hormone may play a role in helping the brain produce new cells, according to a new study published this week in the online edition of the Proceedings of the National Academy of Sciences (PNAS).
The new work, conducted by a team of scientists at the University of Wisconsin-Madison, provides some of the first direct evidence of the biological effects of DHEA on the human nervous system, according to Clive Svendsen, the study’s senior author and an authority on brain stem cells at UW-Madison’s Waisman Center.
“What we saw was that DHEA significantly increased the division of the cells,” said Svendsen, a UW-Madison professor of anatomy and neurology. “It also increased the number of neurons produced by the stem cells, prompting increased neurogenesis of cells in culture.”
DHEA or dehydroepiandrosterone is among the most abundant naturally occurring steroids in the blood of young humans, but levels decline with age and its physiological effects are poorly understood.
A synthetic form of the hormone is sold over-the-counter as a dietary supplement in the US, thought to have anti-aging properties and to offer prevention against cancer and heart disease, Alzheimer’s and other diseases. But scientists know relatively little about the drug and its basic biological effects on humans.
“We don’t know much about DHEA, but this new work adds a piece to the puzzle,” said Svendsen, who conducted the study with colleagues Masatoshi Suzuki, Lynda S. Wright, Padma Marwah and Henry A. Lardy, all of UW-Madison. “This is the first real evidence of DHEA’s effects on human neural cells.”
Svendsen and Suzuki carried out the experiments by growing human fetal neural stem cells in culture. The cells form aggregates known as ‘neurospheres,’ which were exposed to a cocktail of DHEA and growth and inhibitory factors, and observed a 29 per cent increase in new brain cells compared to cells grown in a medium with the same factors, but without DHEA.
“We saw such a pure effect of DHEA,” Svendsen said.
“It’s the only steroid we tested that had such a direct effect on stem cell growth and new neuron formation,” according to Suzuki.
The new work is important because it provides a direct window to the controversial hormone’s effects on critical human cells. Similar studies have been conducted in mice and rats, but those models have shortcomings that are difficult to address, Svendsen notes.
“There are previous studies in rats that suggest DHEA is neuroprotective, but the problem with DHEA in rats is that it is not a major metabolite in that animal so its effects may not be the same as those seen in humans,” he said. According to Lardy, metabolic products of DHEA hormone have also been shown to aid memory retention in old mice.
Despite hints from the studies in rodents that DHEA may play a role in enhancing the brain and memory, the new findings reported in the PNAS article were a surprise, he said.
“We assumed the compounds we were testing would be more active than DHEA in brain stem cells,” Lardy explains. In previous studies, Lardy, with Wisconsin biochemistry colleagues James Ntambi and Brian Fox, showed that DHEA blocked a step in fat synthesis.
“The effects of DHEA on brain stem cells is a completely new finding,” said Lardy. “The problem of whether DHEA itself is having this effect, or if there’s another metabolite of the hormone involved, still exists.”
One of the intriguing aspects of the new work, according to Svendsen, is the possibility that DHEA could have some positive effects on the adult human brain.
It is known that DHEA amounts fall progressively during aging, and reduced levels of DHEA have been reported in both adolescents and adults with major depressive disorders. And given the fact that adult humans have neural stem cells that continue to make new neurons in some parts of the brain, there is a possibility that DHEA could play a role in moderating the genesis of new brain cells.