Ellagic Acid: Anti-Cancer Supplement
ELLAGIC ACID IS A POWERFUL ANTI-CANCER SUPPLEMENT SLOAN-KETTERING CLINICAL SUMMARY
A phenolic compound derived from ellagitannins commonly found in red raspberries, strawberries and walnuts. Ellagic acid has antiviral and antibacterial properties (1) (2). Recent studies have indicated that ellagic acid may have anticarcinogenic effects against liver, esophageal, prostate, and colorectal cancer cell lines (3) (4) (5) (6). Other studies have reported that ellagic acid is a potent antioxidant (1) (7). The anticancer properties of ellagic acid have not been established in humans. Ellagic acid obtained from dietary sources appears to be safe, but its long-term toxicity effects have not been evaluated. FOOD SOURCES Red raspberries, strawberries, terminalia chebula, pomegranates, walnuts. USES Cancer prevention CONSTITUENTS Ellagic acid. MECHANISM OF ACTION Ellagic acid appears to inhibit chemical-induced esophageal carcinogenesis in animals (8). It down-regulates insulin-like growth factor IGF-II (6) and activates p53/p21 expression, leading to cell cycle arrest at the G1/S phase and apoptosis (9). In vitro studies report that ellagic acid protects cells from oxidative DNA damage caused by hydrogen peroxide and bleomycin (7). Ellagic acid
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